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Division of Health AIDivision of Health AI

Clinical AI built with the data and clinicians of one of the largest health systems in the United States.

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Affiliations

  • Feinstein Institutes↗ (opens in new tab)
  • Northwell Health↗ (opens in new tab)
  • Zucker School of MedicineHofstra Northwell

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  • Institute of Health System Science
  • Institute of Bioelectronic Medicine
  • Manhasset, New York

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Preclinical AI · Active

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Vagus decoding: metabolic states (preclinical)

Preclinical research using decoding algorithms to identify neural signals from the vagus nerve that respond specifically to hypoglycemia. A decoder achieved high accuracy in reconstructing blood glucose levels from vagus nerve recordings, with median error of 18.6 mg/dL, and revealed that TRPV1 nociceptor neurons are critical for sensing low glucose states.

2 researchers·1 publication·3 figures

HYPOGLYCEMIAGLUCOSE
Preclinical AIDivision of Health AI
Measured blood glucose versus glucose reconstructed from vagal nerve signals during insulin-induced hypoglycemia.
Measured blood glucose versus glucose reconstructed from vagal nerve signals during insulin-induced hypoglycemia. Bioelectronic Medicine, 2019 · CC BY 4.0 (opens in new tab)
The neural decoder: sliding windows of compound action potential rates fed through lasso regression with cross-validation.
The neural decoder: sliding windows of compound action potential rates fed through lasso regression with cross-validation. Bioelectronic Medicine, 2019 · CC BY 4.0 (opens in new tab)
Compound action potential rates rise after insulin but not saline, showing the vagal response is specific to hypoglycemia.
Compound action potential rates rise after insulin but not saline, showing the vagal response is specific to hypoglycemia. Bioelectronic Medicine, 2019 · CC BY 4.0 (opens in new tab)

From the papers

Published figures

Figures reproduced from the open-access papers behind this project.

Each panel keeps its original source and license. Scroll the column at left to move through the published results while these notes stay in view.

People · 2

On this project

Theodoros Zanos, PhD

Professor & AVP

Todd Levy, MS

Senior Biomedical Engineer

Publications · 1

Related papers

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Bioelectronic MedicineJul 2019

Identification of hypoglycemia-specific neural signals by decoding murine vagus nerve activity

(opens in new tab)

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Vagus decoding: inflammation (preclinical)

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Chronic vagus nerve recordings (mouse)