Preclinical AI · Active
All researchChronic wireless recording of compound action potentials from the mouse vagus nerve up to 6 months, enabling longitudinal tracking of neural activity in disease models (CIA, CAIA) to predict inflammation severity and evaluate neuromodulation efficacy.
3 researchers6 publications3 figures



From the papers
Figures reproduced from the open-access papers behind this project.
Each panel keeps its original source and license. Scroll the column at left to move through the published results while these notes stay in view.
People · 3
Publications · 6
Related
This research decodes how vagus nerve neurons sense inflammatory cytokines in real time, enabling development of diagnostic bioelectronic devices and closed-loop inflammation treatments. Building on prior work showing vagal decoding of immune signals, recent studies reveal that individual vagal sensory neurons selectively respond to specific cytokines, with altered responses during active inflammation.
Preclinical AI
Preclinical research using decoding algorithms to identify neural signals from the vagus nerve that respond specifically to hypoglycemia. A decoder achieved high accuracy in reconstructing blood glucose levels from vagus nerve recordings, with median error of 18.6 mg/dL, and revealed that TRPV1 nociceptor neurons are critical for sensing low glucose states.
Preclinical AI