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Division of Health AIDivision of Health AI

Clinical AI built with the data and clinicians of one of the largest health systems in the United States.

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Affiliations

  • Feinstein Institutes↗ (opens in new tab)
  • Northwell Health↗ (opens in new tab)
  • Zucker School of MedicineHofstra Northwell

Located at

  • Institute of Health System Science
  • Institute of Bioelectronic Medicine
  • Manhasset, New York

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Preclinical AI · Active

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Chronic vagus nerve recordings (mouse)

Chronic wireless recording of compound action potentials from the mouse vagus nerve up to 6 months, enabling longitudinal tracking of neural activity in disease models (CIA, CAIA) to predict inflammation severity and evaluate neuromodulation efficacy.

3 researchers·6 publications·3 figures

M1M2M3M4M5M6CAP
Preclinical AIDivision of Health AI
Heart rate threshold and electrical impedance stay stable for eight or more weeks after implantation.
Heart rate threshold and electrical impedance stay stable for eight or more weeks after implantation. eLife, 2021 · CC BY 4.0 (opens in new tab)
Vagus nerve stimulation suppresses serum TNF in endotoxemia versus sham in chronically implanted animals.
Vagus nerve stimulation suppresses serum TNF in endotoxemia versus sham in chronically implanted animals. eLife, 2021 · CC BY 4.0 (opens in new tab)
Histology of the implanted vagus nerve shows preserved fibers and intact neurofilaments at three weeks.
Histology of the implanted vagus nerve shows preserved fibers and intact neurofilaments at three weeks. eLife, 2021 · CC BY 4.0 (opens in new tab)

From the papers

Published figures

Figures reproduced from the open-access papers behind this project.

Each panel keeps its original source and license. Scroll the column at left to move through the published results while these notes stay in view.

People · 3

On this project

Theodoros Zanos, PhD

Professor & AVP

Todd Levy, MS

Senior Biomedical Engineer

Shubham Debnath, PhD

Senior Research Scientist

Publications · 6

Related papers

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International Journal of Neural SystemsDec 2025

Longitudinal characterization of compound action potentials in chronic vagus nerve recordings in mice

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Biosensors and BioelectronicsDec 2021

A fully implantable wireless bidirectional neuromodulation system for mice

(opens in new tab)
eLifeApr 2021

Development and characterization of a chronic implant mouse model for vagus nerve stimulation

(opens in new tab)
Brain StimulationSep 2020

Quantitative estimation of nerve fiber engagement by vagus nerve stimulation using physiological markers

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Journal of Neuroscience MethodsOct 2019

An impedance matching algorithm for common-mode interference removal in vagus nerve recordings

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International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS)Jun 2017

A new 3D self-adaptive nerve electrode for high density peripheral nerve stimulation and recording

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Vagus decoding: metabolic states (preclinical)

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